“No significant difference was observed between the four groups by macroscopic examination. The area of skin defect of the treated groups was significantly smaller than that of the control groups (p < 0.05) from the 1st-13th day after irradiation. For both irradiated and non-irradiated skin defects of treatment groups, Group III was smaller than Group II (p < 0.05) and Group IV was smaller than Group II (p < 0.05) Histological examination of the tissue skin defect showed greater proliferation of connective tissue and blood vessels in the dermis in treated groups than in control."